PRosPERoS-II is a large research project led by Maastricht UMC+ in the field of ‘smart,’ 3D-printed implants for orthopedic applications. The research focuses on the development of biologically active implants that can be customized to the needs of each individual patient, leading to faster rehabilitation and a reduction in the need for additional surgeries. As a result, PRosPERoS-II will make a significant societal contribution to healthy aging.